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Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy Review

Feng Xie, Rui Liang, Dan Li, Bin Li

Engineering 2019, Volume 5, Issue 1,   Pages 132-139 doi: 10.1016/j.eng.2018.12.002

Abstract:

Cancer is a potentially life-threatening disease characterized by the immortalization of tumor cellsRegulatory T cells (Tregs) are a subgroup of suppressive CD4+ T cells that play a vital role in the maintenanceopportunities for improving antitumor efficiency in combination with other therapeutics (e.g., Car-T-based

Keywords： Regulatory T cells     Cancer     Immunotherapy    

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Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in Review

Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

Engineering 2022, Volume 10, Issue 3,   Pages 30-43 doi: 10.1016/j.eng.2021.10.018

Abstract: Cells expressing these receptors are rerouted to a predefined target by the inclusion of an antigen-specificThe advantage of cells with programmed specificity has been demonstrated clinically in the field of oncology, and it is clear that such cells have greater accuracy, potency, and reduced off-target therapeuticIn contrast to conventional T cells (Tconvs), regulatory T cells (Tregs) play a major role in suppressing

Keywords： Chimeric antigen receptors     T cell     Treg     Alloimmunity     Bioengineering     Transplant     Autoimmunity    

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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: cells and antibody-producing B cells) achieve viral clearance and host recovery.Adaptive T and B cells maintain immunological memory and provide protection against subsequent infectionsRecent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptiveCD8+ and CD4+ T cells, and discuss how these responses can be harnessed by novel

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

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γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 262-268 doi: 10.1007/s11684-017-0584-x

Abstract:

γδ T cells display unique developmental, distributional, and functional patterns and canγδ T cells are enriched in the liver and exhibit liver-specific features.In this study, we review the properties of hepatic γδ T cells and summarize the roles ofγδ T cells in liver diseases.We believe that determining the properties and functions of γδ T cells in liver diseases

Keywords： γδT cells     liver infection     non-alcoholic fatty liver disease     autoimmune hepatitis     liver fibrosis and cirrhosis    

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Liver cell therapies: cellular sources and grafting strategies

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 432-457 doi: 10.1007/s11684-023-1002-1

Abstract: liver and that are helped through interactions with non-parenchymal cell types comprising stellate cellsThe regulation of the cells in the liver is mediated by an insoluble complex of proteins and carbohydratesdevelopment of genetic sequencing technologies, research on the liver’s cellular composition and its regulatoryreview will focus on the cellular mechanisms of liver homeostasis and how to select ideal sources of cells

Keywords： liver regeneration     hepatocytes     cholangiocytes     stem cells     organoids     regulatory mechanisms     transplantation    

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High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells

Synat Kang, Yanyan Li, Yifeng Bao, Yi Li

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 69-82 doi: 10.1007/s11684-018-0677-1

Abstract:

Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapyThe low-efficacy problem can be resolved using T cell antigen receptor-engineered CAT (TCR-CAT).165 HLA-A*02:01-specific high-affinity TCR (HAT)-transduced CATs can specifically kill cancer cellsTCR-CATs delivered significantly better activation and cytotoxicity than the equivalent TCR-engineered Tcells (TCR-Ts) in terms of interferon-g and granzyme B production

Keywords： cytokine-activated T cells     high-affinity T cell receptor     cancer immunotherapy     TCR-CAT    

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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 726-745 doi: 10.1007/s11684-020-0746-0

Abstract: Chimeric antigen receptor (CAR) T cells have been indicated effective in treating B cell acute lymphoblasticHowever, CAR T cells have achieved minimal success against solid malignancies because of the additionalMobilization of endogenous immune cells is also necessary for CAR T cells to obtain their optimal therapeuticthe immune response in solid malignancies, especially with CAR T cells acting as cellular carriers toFinally, we discuss the combination of CAR T cells with biomaterials or oncolytic viruses to enhance

Keywords： CAR T cells     immunoregulatory molecules     endogenous immune response     solid malignancies    

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CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 783-804 doi: 10.1007/s11684-021-0904-z

Abstract: Chimeric antigen receptor T-cell (CAR T) immunotherapy opens a new path for targeted therapy of hematologicalIn this review, through a representative case study, we summarize the current experience of CAR T-cell, the causative mechanisms of therapy resistance, and new strategies to improve the efficacy of CAR T-cell

Keywords： CAR T cells     hematological malignancies     review    

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Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 366-369 doi: 10.1007/s11684-008-0070-6

Abstract: The effect of transfected CD4 T cells on the proliferation and cytokine production of CD4CD25 T cellsAfter transfection, the proliferation of CD4 T cells was eliminated.Transfected T cells inhibited the proliferation of CD4CD25 T cells.CD4CD25 T cells acquired a regulatory phenotype and function after it was transduced with the Foxp3 geneThis suggested a key role of Foxp3 in the generation of CD4CD25 regulatory T cells.
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Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 374-386 doi: 10.1007/s11684-018-0652-x

Abstract: suppressors in the development of Burkitt’s lymphoma in humans, and hepatosplenic and innate-like TWe re-examine the derailment of these regulatory mechanisms in lymphocytes that facilitate tumor development

Keywords： Id proteins     lymphoma     leukemia     T cells     B cells     tumor suppressor     oncogene    

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Th17 Cells in autoimmune diseases

Lei Han,Jing Yang,Xiuwen Wang,Dan Li,Ling Lv,Bin Li

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 10-19 doi: 10.1007/s11684-015-0388-9

Abstract:

Th17 cells are a new subset of CD4+ T cells involved in the clearance of extracellularAccumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the

Keywords： IL-17     Th17 cells     RORγt     autoimmune diseases     posttranslational modification     inhibitors    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract:

Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigensNatural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolicIn this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitiscells during the progression of liver diseases, which might be caused by changes in natural killer Tsubsets, factors skewing cytokine responses, and intercellular crosstalk between natural killer T cells

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholic    

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Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 33-39 doi: 10.1007/s11684-011-0114-1

Abstract:

Adult stem cells hold great promise for wound healing and tissue regeneration.Mesenchymal stem cells (MSCs), for example, have been shown to play a role in tissue repair.This review will briefly summarize the regulatory facors and signaling transduction pathways involved

Keywords： mesenchymal stem cells     migration     molecular mechanisms     signaling pathway    

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The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 190-200 doi: 10.1007/s11684-014-0323-5

Abstract: Moreover, some stem cell-based products have been approved for marketing by different national regulatoryexist and need to be urgently addressed, especially in countries where establishment of appropriate regulatoryMore relevantly, the stem cell regulatory sciences need to be established or improved to more effectivelyevaluate quality, safety and efficacy of stem cell products, and for building up the appropriate regulatoryregulations, and the associated challenges, and we then propose some considerations for improving stem cell regulatory

Keywords： cell-based medicinal products (SCMPs)     stem cell therapy (SCT)     safety     effectiveness     standards     guidelines     regulatory    

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: To date, six chimeric antigen receptor T cell (CAR-T) therapies have been permitted for the treatmentHowever, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or theyThe simultaneous expression of target antigens by healthy organs and tumor cells is partly responsibleglycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-TTn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis,

Keywords： cancer immunotherapy     chimeric antigen receptor     solid tumors     tumor-associated antigen     glycosylation     O-glycans     adoptive cell therapy    

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Title Author Date Type Operation

Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy

Feng Xie, Rui Liang, Dan Li, Bin Li

Journal Article

Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in

Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Journal Article

Liver cell therapies: cellular sources and grafting strategies

Journal Article

High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells

Synat Kang, Yanyan Li, Yifeng Bao, Yi Li

Journal Article

Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Journal Article

CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Journal Article

Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Journal Article

Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Journal Article

Th17 Cells in autoimmune diseases

Lei Han,Jing Yang,Xiuwen Wang,Dan Li,Ling Lv,Bin Li

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction

Li LI, Jianxin JIANG

Journal Article

The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Journal Article

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

Journal Article